33x12.50R22 is 1.80" shorter than 325/50R22, a −5.16% change in diameter. That is more than the 3% many tire shops use as a limit, so plan on recalibrating the speedometer and checking ABS and stability control.
Ground clearance changes by 0.90" (half the diameter change), and the tire needs 0.90" less room above it.
325/50R22 is 0.30" wider. On the same wheel offset about half of that, 0.15", moves toward the suspension and half toward the fender.
Both fit a 22" wheel; the sidewall is 0.90" shorter on 33x12.50R22.
Details: 325/50R22 in inches · 33x12.50R22 in inches · change sizes in the calculator